Left click randomly not working

I have had this issue twice now where left click while using WASD stops working. I cant get it to turn back on in the options screen because its greyed out, switching it with other key binds also does not work. There are other suggestions on line but so far none of them are working. The only fix I found was to uninstall and reinstall the game. This obviously isn't intended but it is pretty inconvenient to have to reinstall over and over just to be able to left click.