Crystal Shard Major Boon didn't trigger

I have the Crystal Shard major boon but it didn't trigger when I got the next affliction (Purple smoke). The major boon wasn't consumed and the affliction wasn't converted either.

Other info:
Active Boons:
Hare Foot
Flooding Rivers
Scrying Crystal
Silver Tongue
Viscous Icor
Sanguine Vial
Ornate Dagger
Adrenaline Vial
Upward Path

Active Afflications:
Red Smoke

Active Major Afflications:
Death Toll

No unique relics.